A method of hormone suppression in humans

Details A method of hormone suppression in humans A method of hormone suppression in humans

A - Human Necessities

61

K

A61K 31/198 (2006.01) A61P 15/00 (2006.01) A61P 15/08 (2006.01) A61P 15/18 (2006.01)

Patent

CA 2703497

The present invention relates to a glycine transporter-1 inhibitor having the formula (I) wherein X is 1-3 substituents selected from H, halogen, methyl, methoxy, trifluoromethyl and trifluoromethoxy and Y is 1-3 substituents selected from H, methyl and halogen or a pharmaceutically acceptable salt thereof for use in a treatment in humans to suppress the level of one or more hormone selected from luteinizing hormone, follicle-stimulating hormone, estradiol and testosterone. The present invention further relates to such a glycine transporter-1 inhibitor as part of a contraceptive regimen or as a treatment for hypersexuality.

La présente invention porte sur un inhibiteur du transporteur 1 de glycine ayant la formule (I) dans laquelle X désigne 1-3 substituants choisis parmi H, halogène, méthyle, méthoxy, trifluorométhyle et trifluorométhoxy et Y désigne 1-3 substituants choisis parmi H, méthyle et halogène ou un sel pharmaceutiquement acceptable de ceux-ci en vue d'une utilisation dans un traitement chez les êtres humains pour diminuer le taux d'une ou plusieurs hormones choisies parmi l'hormone lutéinisante, l'hormone de stimulation folliculaire, l'stradiol et la testostérone. La présente invention porte en outre sur un inhibiteur du transporteur 1 de la glycine en tant que partie d'un régime contraceptif ou en tant que traitement pour l'hypersexualité.

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