C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/02 (2006.01) C12M 3/04 (2006.01)
Patent
CA 2308111
A method for enhancing the mixing of materials in roller bottle by the introduction of controlled axial and cross-sectional flow perturbations is disclosed. The effectiveness of the method is demonstrated by achieving higher efficiency in cell culturing and virus propagation in roller bottles by introducing controlled flow perturbations during the process.
L'invention concerne un procédé permettant d'améliorer le mélange de substances dans une bouteille pour agitateur rotatif, ce procédé consistant à introduire de manière régulée des perturbations selon des écoulements axial et transversal. L'efficacité de ce procédé se traduit par un rendement amélioré des mises en culture cellulaire et une meilleure propagation virale dans les bouteilles pour agitateur rotatif, grâce à l'introduction des perturbations susmentionnées au cours du processus.
Bramble Joye L.
Muzzio Fernando J.
Searles James A.
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Rutgers The State University Of New Jersey
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