A method of inducing an immune response using vaccinia virus...

Details A method of inducing an immune response using vaccinia virus... A method of inducing an immune response using vaccinia virus...

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 31/70 (2006.01) A61K 38/19 (2006.01)

Patent

CA 2190290

A method of inducing expression of immune active cytokines in tumors in situ is provided wherein a vaccinia virus vector capable of inducing expression of a selected cytokine is generated and injected into a tumor so that cells of the tumor express the selected cytokine. A method of enhancing immunity in a host by administration of a vaccinia virus vector is also provided. Methods of treating cancer by administration of these vaccinia virus vectors are also provided.

L'invention concerne un procédé permettant d'induire l'expression de cytokines immuno-actives dans des tumeurs in situ, procédé selon lequel un vecteur viral vaccinal pouvant induire l'expression d'une cytokine sélectionnée est produit et injecté dans une tumeur pour que les cellules de la tumeur expriment la cytokine sélectionnée. L'invention concerne également un procédé permettant d'augmenter l'immunité d'un hôte par administration d'un vecteur viral vaccinal. L'invention concerne en outre des procédés de traitement du cancer par administration de ces vecteurs viraux vaccinaux.

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