A method of inducing or enhancing chondrogenesis with...

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A61K 38/00 (2006.01) C12N 5/077 (2010.01) A61K 35/12 (2006.01) A61K 35/32 (2006.01) A61K 38/18 (2006.01) A61K 38/39 (2006.01) C07K 17/02 (2006.01)

Patent

CA 2346119

A method and composition are provided for inducing or enhancing chondrogenesis in vivo or in vitro. The method is performed by exposing the cells in vitro or in vivo to an extracellular matrix comprising of type I collagen, type II collagen or a mixture of type I collagen or type II collagen and hyaluronate and further containing GDF-5.

L'invention concerne un procédé et une composition servant à déclencher ou à renforcer la chondrogenèse in vivo ou in vitro. Le procédé comporte l'étape consistant à exposer les cellules in vitro ou in vivo à une matrice extracellulaire constituée de collagène de type I, de collagène de type II ou d'un mélange de collagène de type I ou de type II et d'hyaluronate, et contenant en outre GDF-5.

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