A method of limiting the survival of genetically engineered...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/63 (2006.01) A01N 63/00 (2006.01) A61K 39/00 (2006.01) C12N 1/15 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 9/22 (2006.01) C12N 15/00 (2006.01) C12N 15/55 (2006.01)

Patent

CA 2133345

The survival of cells is limited by introducing into the cells a regulatably expressible gene whose expression results in the formation of a cytoplasmatically active hydrolytic enzyme. Populations of cells containing, in addition to such a regulatably expressible gene, a DNA coding for an immunologically active, pesticidally active or environmental pollutant-degarding gene product, may be useful in immunologically active compositions, pesticidally active compositions and environmental pollutant-degrading compositions, respectively.

Procédé de limitation de la survie de cellules, consistant à introduire dans les cellules un gène à expression régulable dont l'expression entraîne la formation d'une enzyme hydrolytique à activité cytoplasmatique. Les populations de cellules contenant, outre ce gène à expression régulable, un ADN codant pour un produit génique à activité immunologique, à activité pesticide ou à activité de dégradation des polluants de l'environnement, sont utilisables dans les compositions ayant respectivement une activité immunologique, une activité pesticide et une activité de dégradation des polluants de l'environnement.

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