A method of making biocompatible capsules containing cells

Details A method of making biocompatible capsules containing cells A method of making biocompatible capsules containing cells

C - Chemistry, Metallurgy

12

N

C12N 11/04 (2006.01) A61K 9/16 (2006.01) A61K 9/50 (2006.01) A61K 35/39 (2006.01) C08B 37/04 (2006.01)

Patent

CA 2115664

2115664 9303710 PCTABS00020 There is disclosed a method of making biocompatible capsules containing cells comprising the steps of suspending cells in an aqueous medium containing a pre-dialysed water soluble gum which has plural anionic moieties but is substantially protein free, forming the suspension into droplets containing the cells, subjecting the droplets to a solution of mutlivalent physiologically compatible cations to gel the droplets, encapsulating said cells, subjecting said gelled droplets to a polymer containing cationic groups which cross-link with said anionic groups to form a semi-permeable membrane and coating said semi-permeable membrane with a layer of said pre-dialysed water soluble gum.

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