A method of microencapsulation

Details A method of microencapsulation A method of microencapsulation

A - Human Necessities

61

K

A61K 9/50 (2006.01) A61K 9/16 (2006.01)

Patent

CA 2389688

A method for microencapsulation of substances is provided. The substance(s) is/are dissolved or dispersed in an organic solvent of the kind that is partially miscible in water media. This organic solution is then mixed with an aqueous solution, which is saturated with an organic solvent and an emulsifier to form an emulsion. The emulsion is then poured into water under continuous agitation for the extraction of residual solvent. The formation of the solid capsules takes place during this extraction process. The capsules are undergone to further purification, whereby the microcapsules can be separated from the water and dried. By conditions of incubation of microcapsules in water-containing formulations the wall-softening process takes place. The unique system for controlled releasing the ingredients from microcapsules is based on the above-mentioned process.

La présente invention concerne un procédé de microencapsulation de substances. La/les substance(s) est/sont dissoute(s) ou dispersée(s) dans un solvant organique du type partiellement miscible dans un milieu aqueux. Cette solution organique est alors mélangée à une solution aqueuse, qui est saturée avec un solvant organique et un émulsifiant pour former une émulsion. L'émulsion est alors versée dans de l'eau sous agitation continue permettant l'extraction du solvant résiduel. La formation de capsules solides s'effectue durant ce processus d'extraction. Les capsules sont soumises à une purification supplémentaire, les microcapsules pouvant être séparées de l'eau et séchées. Les conditions d'incubation de microcapsules dans des formulations contenant de l'eau permettent au processus de ramollissement de paroi de s'effectuer. Le système unique de libération contrôlée des ingrédients contenus dans les microcapsules se base sur le procédé mentionné ci-dessus.

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