A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/45 (2006.01) A61K 31/407 (2006.01) A61K 31/4355 (2006.01) A61K 38/18 (2006.01) A61P 3/04 (2006.01) A61P 9/14 (2006.01) A61P 27/00 (2006.01) A61P 29/00 (2006.01) A61P 35/04 (2006.01)
Patent
CA 2497836
The present invention relates generally to a method of modulating endothelial cell activity and to agents useful for same. More particularly, the present invention relates to a method of modulating intercellular vascular endothelial permeability by modulating an intracellular protein kinase C-dependent signalling mechanism. The method for the present invention is useful, inter alia, in the treatment and/or prophylaxis of a condition characterised by aberrant, unwanted or otherwise inappropriate endothelial cell activity, in particular, conditions characterised by a loss of vascular integrity.
L'invention porte sur un procédé de modulation de l'activité cellulaire endothéliale et sur des agents utiles à la modulation. Plus précisément, l'invention concerne un procédé de modulation de la perméabilité endothéliale vasculaire intercellulaire par modulation d'un mécanisme de signalement dépendant de la protéine kinase C intercellulaire. Ce procédé est utile, entre autres, au traitement et/ou à la prophylaxie d'une condition caractérisée par une activité cellulaire aberrante, indésirable ou inappropriée, notamment des conditions caractérisées par une perte d'intégrité vasculaire.
Gamble Jennifer Ruth
Vadas Mathew Alexander
Xiaochun Li
Fetherstonhaugh & Co.
Medvet Science Pty. Ltd.
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