C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/48 (2006.01)
Patent
CA 2519359
The present invention relates generally to a method of modulating smooth muscle cell functioning and agents useful for same. More particularly, the present invention relates to a method of modulating smooth muscle tone by modulating intracellular sphingosine kinase mediated signalling. The method of the present invention is useful, inter alia, in the treatment and/or prophylaxis of conditions characterised by aberrant, unwanted or otherwise inappropriate smooth muscle tone, in particular aberrant, unwanted or otherwise inappropriate vascular, bronchial or intestinal smooth muscle tone.
L'invention a trait à un procédé de modulation du fonctionnement des cellules des muscles lisses, et à des agents associés. Plus précisément, la présente invention concerne un procédé permettant de moduler la tonicité des muscles lisses, par la modulation de la signalisation intracellulaire assurée par la sphingosine kinase. Le procédé selon l'invention est utile, entre autres, pour traiter et/ou prévenir des troubles caractérisés par une tonicité des muscles lisses aberrante, non désirée ou inappropriée, en particulier par une tonicité des muscles lisses vasculaires, bronchiques ou intestinaux aberrante, non désirée ou inappropriée.
Bolz Steffen-Sebastian
Pitson Stuart M.
Fetherstonhaugh & Co.
Medvet Science Pty. Ltd.
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