A method of pre-sensitizing cancer prior to treatment with...

Details A method of pre-sensitizing cancer prior to treatment with... A method of pre-sensitizing cancer prior to treatment with...

A - Human Necessities

61

K

A61K 45/00 (2006.01) A61K 38/21 (2006.01)

Patent

CA 2531322

This invention relates to a breakthrough method for pre-sensitizing cancer prior to a therapeutic treatment such as chemotherapy, radiation therapy or immuno-therapy and a novel cytokine mixture used in the method thereof. The cytokine mixture is a serum-free and mitogen-free mixture comprised of specific ratios of cytokines such as IL-1.beta. , TNF-.alpha., IFN-.gamma. and GM-CSF to Interleukin 2 (IL-2), which is effective in inducing cancerous cells to enter a proliferative cell cycle phase thereby increasing their vulnerability to chemotherapy, radiation therapy and immuno-therapy. One such novel cytokine mixture is Multikine®, which can be used alone or in combination with other drugs for the treatment of cancer thereby increasing the success of cancer treatment and the disease free survival of cancer patients.

Cette invention concerne une méthode révolutionnaire visant à pré-sensibiliser un cancer avant un traitement tel qu'une chimiothérapie, une radiothérapie ou une immunothérapie ainsi qu'un nouveau mélange de cytokine utilisé conjointement avec cette méthode. Le mélange de cytokine est un mélange exempt de sérum et de mitogène présentant des rapports spécifiques de cytokines telles que IL-1.szlig. , TNF-a, IFN-? et GM-CSF à l'interleukine 2 (IL-2), ce qui permet efficacement de faire entrer ces cellules cancéreuses dans un phase de cycle de prolifération cellulaire et d'accroître la vulnérabilité desdites cellules à la chimiothérapie, à la radiothérapie et à l'immunothérapie. L'un de ces nouveaux mélanges de cytokine est la Multikine®, qui peut être utilisée seule ou combinée à d'autres médicaments anti-cancéreux et qui augmente les chances de réussite du traitement et de survie sans maladie de patients atteints du cancer.

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