A method of preparation of...

C - Chemistry – Metallurgy – 07 – C

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C07C 303/40 (2006.01) C07C 311/37 (2006.01)

Patent

CA 2554851

A method of preparation of (R)-(-)-5-(2-aminopropyl)-2- methoxybenzenesulfonamide of formula I and its use for production tamsulosin. A protective group is introduced to N-[(1R)-2~(4-methoxyphenyl)-1-methylethyl]- N- [(1 R)-1-phenylethyl)]amine and the resulting amide of formula IX is chlorosulfonated and the resulting sulfochloride is converted to a sulfonamide of formula X, from which the compound of formula I is obtained by hydrogenation.

La présente invention concerne un procédé de préparation de (R)-(-)-5-(2-aminopropyl)-2-méthoxybenzènesulfonamide représenté par la formule I, ainsi que son utilisation pour la production de tamsulosine. Un groupe protecteur est introduit dans N-[(1R)-2-(4-méthoxyphényl)-1-méthyléthyl]-N- [(1 R)-1-phényléthyl)]amine et l'amide obtenu représenté par la formule IX est chlorosulfoné, puis le sulfochlorure obtenu est transformé en un sufolnamide représenté par la formule X, à partir duquel le composé représenté par la formule I est obtenu par hydrogénation.

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