A method of preparing multi-modal anion-exchange ligands

Details A method of preparing multi-modal anion-exchange ligands A method of preparing multi-modal anion-exchange ligands

B - Operations, Transporting

01

J

B01J 20/30 (2006.01) B01D 15/36 (2006.01) B01J 20/281 (2006.01) B01J 41/04 (2006.01)

Patent

CA 2517732

The invention relates to a method of preparing multi-modal anion-exchange ligands, which comprises providing a cyclic three-functional scaffold comprising an amine, a carbonyl and a thiol; optionally derivatisation of the amine of the scaffold to provide an anion-exchanging group and/or to protect the amine; and aminolysis to open up the derivative by adding a reagent comprising an amine coupled to a residue R in order to add said amine to the carbonyl carbon of the opened scaffold. The scaffold is advantageously homocysteine thiolactone. In one embodiment, the method comprises an additional step of immobilising the opened scaffold to a base matrix to provide a separation medium, such as a chromatography medium.

Cette invention concerne un procédé de préparation de ligands échangeurs d'anions multimodaux, qui consiste à: mettre en oeuvre un échafaudage trifonctionnel cyclique comprenant un amine, un carbonyle et un thiol; dériver éventuellement l'amine de l'échafaudage pour obtenir un groupe échangeur d'anions et/ou pour protéger l'amine; et réaliser une aminolyse en vue d'ouvrir le dérivé par adjonction d'un réactif comprenant un amine couplé à un résidu R afin d'ajouter ledit amine au carbone de carbonyle de l'échafaudage ouvert. L'échafaudage est avantageusement un homocystéine thiolactone. Dans un mode de réalisation, le procédé met en oeuvre un support de séparation, tel qu'un support chromatographique.

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