A method of preservation of vaccines with polybiguanide

A - Human Necessities – 61 – K

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Details

A61K 39/12 (2006.01) A61K 39/145 (2006.01) A61K 47/18 (2006.01) A61L 2/00 (2006.01) A61K 9/00 (2006.01)

Patent

CA 2284028

The invention provides a method of preventing or reducing bacterial contamination of a viral vaccine, which method comprises adding to a solution containing vaccine virus or virus antigen an effective preserving amount of a preservative composition containing a polybiguanide. The method is particularly useful for preventing or reducing bacterial contamination of process solutions during the manufacture of influenza vaccines.

L'invention concerne une méthode de prévention ou de réduction d'une contamination bactérienne d'un vaccin viral. Cette méthode consiste à ajouter dans une solution contenant un virus de vaccination ou un antigène viral une quantité effective d'une composition préservative contenant un polybiguanide. Cette méthode convient particulièrement pour la prévention ou la réduction d'une contamination bactérienne de solutions de processus pendant la fabrication de vaccins contre la grippe.

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