A method of preventing abuse of opioid dosage forms

Details A method of preventing abuse of opioid dosage forms A method of preventing abuse of opioid dosage forms

A - Human Necessities

61

K

A61K 31/485 (2006.01) A61K 31/44 (2006.01)

Patent

CA 2314896

The invention relates in part to a method of reducing the abuse potential of an oral dosage form of an opioid analgesic, wherein an analgesically effective amount of an orally active opioid agonist is combined with an opioid antagonist into an oral dosage form which would require at least a two-step extraction process to be separated from the opioid agonist, the amount of opioid antagonist including being sufficient to counteract opioid effects if extracted together with the opioid agonist and administered parenterally.

L'invention porte partiellement sur un procédé de réduction des abus potentiels de doses orales d'analgésiques selon lequel une quantité à effet analgésique d'un agoniste d'opioïde est combinée à antagoniste d'opioïde dans la dose. Cela rend nécessaire une extraction en deux étapes au moins pour effectuer la séparation de l'agoniste d'opioïde, car la quantité d'antagoniste est suffisante pour neutraliser les effets de l'opioïde s'ils sont extraits ensemble et administrés par voie parentérale.

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