A method of producing cells with a desired property by...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/02 (2006.01) C12N 15/00 (2006.01) C12N 15/04 (2006.01) C12Q 1/68 (2006.01) C40B 50/06 (2006.01)

Patent

CA 2331263

The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites.

L'invention concerne des procédés employant des cycles itératifs de recombinaison et de sélection/criblage en vue de faire évoluer des cellules et des organismes entiers de façon qu'ils acquièrent des propriétés voulues. Des exemples de ces propriétés comprennent une capacité de recombinaison génétique améliorée, un nombre de copies de génome, et une capacité d'expression et/ou de sécrétion de protéines et de métabolites secondaires.

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