C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 21/02 (2006.01) C12N 5/10 (2006.01) C12N 15/11 (2006.01)
Patent
CA 2658301
A method of producing a recombinant biological product, which method employs a mammalian producer cell culture, comprises the steps of generating a biomass of mammalian producer during an initial phase of cell culture, and causing an increase in a level of one or more of the miRNA molecules of Table 1 within the mammalian producer cells once a desired concentration of mammalian producer cells has been achieved. The method may also comprise the step of increasing a level of an inhibitor of one or more of the miRNA molecules of Table 1 within the mammalian producer cells at the start of or during an initial phase of culture.
L'invention concerne un procédé d'obtention d'un produit biologique recombinant, lequel procédé emploie une culture de cellules productrices mammifères et comprend les étapes consistant à générer une biomasse de cellules productrices mammifères pendant une phase initiale de culture cellulaire, et à provoquer une augmentation d'un niveau d'une ou plusieurs des molécules d'ARNmi du Tableau 1 à l'intérieur des cellules productrices mammifères après l'obtention d'une concentration désirée de cellules productrices mammifères. Le procédé peut également comporter l'étape consistant à augmenter un niveau d'un inhibiteur d'une ou plusieurs des molécules d'ARNmi du Tableau 1 à l'intérieur des cellules productrices mammifères au démarrage ou pendant une phase initiale de culture.
Barron Niall
Clynes Martin
Gammell Patrick
Dublin City University
Kirby Eades Gale Baker
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