A method of prophylaxis and treatment

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/28 (2006.01) A61K 38/19 (2006.01) A61K 39/00 (2006.01) A61P 3/10 (2006.01) A61P 37/02 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2387652

The present invention relates generally to a method of prophylaxis and treatment of autoimmune disease conditions and agents useful for same. In a related embodiment, the present invention contemplates the use of mucosal antigens and/or agents capable of blocking or otherwise delaying cytotoxic T- lymphocyte (CTL) induction and/or maturation to prevent or at least reduce the likelihood or risk of CTL-mediated autoimmune disease. More particularly, the present invention contemplates mucosa-mediated tolerance to protect against or ameliorate the symptoms associated with autoimmune pathology. Even more particularly, the present invention provides a method for preventing clinical insulin-dependent diabetes mellitus (IDDM) or preventing or reducing or ameliorating the effects of clinical IDDM by the aerosol administration of IDDM-associated autoantigens to mucosal surfaces or agents which block CTL induction and/or maturation.

La présente invention porte sur un procédé de prophylaxie et de traitement de maladies auto-immunes et sur des agents utilisés pour traiter ces maladies. Selon une réalisation, l'invention porte sur l'utilisation d'antigènes des muqueuses et/ou d'agents capables de bloque ou du moins retarder l'induction et/ou la maturation des lymphocytes T cytotoxiques (CTL) pour empêcher ou du moins réduire le risque d'une maladie auto-immune induite par les CTL, Plus spécifiquement, cette invention porte sur la tolérance induite par les muqueuses pour protéger des symptômes associés à une pathologie auto-immune. Et, plus particulièrement, l'invention porte sur un procédé de prévention contre le diabète sucré insulinodépendant clinique, ou de prévention, ou réduction ou amélioration des effets du diabète sucré insulinodépendant clinique en administrant par aérosol des auto-antigènes associés au diabète sucré insulinodépendant sur les surfaces des muqueuses, ou en administrant des agents bloquant l'induction et/ou la maturation des CTL.

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