A method of reducing drug-induced adverse side effects in a...

Details A method of reducing drug-induced adverse side effects in a... A method of reducing drug-induced adverse side effects in a...

A - Human Necessities

61

K

A61K 38/28 (2006.01) A61K 31/155 (2006.01) A61K 31/165 (2006.01) A61K 31/425 (2006.01)

Patent

CA 2584284

The invention relates to the discovery that farnesoid X receptor (FXR) agonists can be used in combination with peroxisome proliferation activated receptor gamma (PPAR.gamma.) agonists to reduce drug-induced adverse side effects in patients suffering from conditions such as insulin resistance, Type II diabetes, metabolic syndrome, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and heart disease. Particularly, the present invention encompasses methods for treating patients suffering from drug-induced adverse side effects with selective PPAR.gamma., dual PPARa/.gamma. and pan PPAR.alpha./.gamma./.delta. agonists in combination with FXR agonists.

L'invention concerne la découverte que les agonistes du récepteur du farnésoïde X (FXR) peuvent être utilisés en combinaison avec des agonistes des récepteurs activateurs de la prolifération des peroxisomes gamma (PPAR.gamma.) afin de réduire les effets secondaires indésirables induits par un médicament chez des patients atteints de pathologies telles que la résistance à l'insuline, le diabète de type II, le syndrome métabolique, la stéatose hépatique non alcoolique (NAFLD), la stéato-hépatite non alcoolique (NASH) et la cardiopathie. La présente invention concerne en particulier des méthodes de traitement de patients atteints d'effets secondaires indésirables induits par un médicament à l'aide d'agonistes de PPAR.gamma., de PPAR.alpha./.gamma. doubles et de PPARa/.gamma./d triples sélectifs, en combinaison avec des agonistes du FXR.

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