A method of reducing the in vivo cholesterol ester transfer...

Details A method of reducing the in vivo cholesterol ester transfer... A method of reducing the in vivo cholesterol ester transfer...

A - Human Necessities

61

K

A61K 31/575 (2006.01) A61K 45/06 (2006.01) A61P 3/06 (2006.01) A61P 9/10 (2006.01)

Patent

CA 2461136

A method of reducing the in vivo cholesterol ester transfer protein mediated transfer of cholesteryl esters between high density lipoproteins (HDL) and low density lipoproteins (LDL) comprises administering a therapeutically effective amount of one or more compounds: formulae (I), (II), (III), wherein R is a sterol or stanol moiety R2 is derived from ascorbic acid and R3 is hydrogen or any metal, alkali earth metal, or alkali metal; and all salts thereof, whereby plasma HDL and LDL are controlled as a result of such administration.

L'invention concerne un procédé permettant de réduire le transfert in vivo d'esters de cholestéryle dont la médiation est assurée par la protéine de transfert des esters de cholestérol, entre les lipoprotéines de haute densité (HDL) et les lipoprotéines de basse densité (LDL). Ce procédé comprend l'étape consistant à administrer une dose thérapeutiquement efficace d'un ou de plusieurs des composés de formules (I), (II), ou (III), dans lesquelles R est un stérol ou une fraction de stanol, R2 est dérivé de l'acide ascorbique et R3 représente un atome d'hydrogène ou un métal quelconque, un métal alcalino-terreux ou un métal alcalin ; ainsi que tous leurs sels, la concentration plasmatique de HDL et de LDL étant vérifiée après ladite administration.

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