A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/17 (2006.01) A61P 17/00 (2006.01) A61P 17/06 (2006.01)
Patent
CA 2759201
Provided are methods of regulating keratinocytes proliferation and differentiation by subjecting keratinocytes to an agent capable of modulating activity or expression of IGFBP7, thereby regulating keratinocytes proliferation and differentiation. Also provided are methods of treating pathologies characterized by hyperproliferative keratinocytes by administering IGFBP7 polypeptide or a polynucleotide encoding IGFBP7 polypeptide to a subject.
La présente invention concerne des procédés de régulation de la prolifération et la différenciation des kératinocytes en exposant les kératinocytes à un agent capable de moduler l'activité ou l'expression de IGFBP7, de manière à réguler la prolifération et la différenciation des kératinocytes. La présente invention concerne des procédés de traitement de pathologies caractérisées par des kératinocytes hyperprolifératifs par administration de polypeptide IGFBP7 ou d'un polynucléotide codant pour un polypeptide IGFBP7 à un sujet.
Nousbeck Janna
Sprecher Eli
And Health Services Fund Of The Te L. Aviv Medical Center The Medical Research Infrastructure
Integral Ip
Rappaport Family Institute For Research In The Medical Sciences
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