A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 31/675 (2006.01) A61P 35/00 (2006.01) C12N 7/01 (2006.01) C12N 9/02 (2006.01) C12N 15/86 (2006.01)
Patent
CA 2197677
A method for selectively killing nervous system and peripheral neoplastic cells is provided. Viral vectors are used to selectively express a cytochrome P450 gene in neoplastic cells, whose gene product targets the cells for selective killing, by rendering the cells sensitive to a chemotherapeutic agent.
Procédé de destruction sélective de cellules néoplasiques dans le système nerveux central et périphérique. Les vecteurs viraux sont utilisés pour exprimer de manière sélective un gène cytochrome P450 dans des cellules néoplasiques dont le produit génétique se dirige contre les cellules devant être détruites de manière sélective en rendant ces cellules sensibles à un agent chimiothérapique.
Breakefield Xandra O.
Chen Ling
Chiocca E. Antonio
Waxman David J.
Wei Ming X.
Boston University
Dana Farber Cancer Institute
Gowling Lafleur Henderson Llp
The General Hospital Corporation
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