A method of stable integration of dna into neurons

Details A method of stable integration of dna into neurons A method of stable integration of dna into neurons

C - Chemistry, Metallurgy

12

N

C12N 15/85 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 14/475 (2006.01) C12N 9/02 (2006.01)

Patent

CA 2266753

The invention relates to the stable transfection of neurons with DNA encoding proliferation cell nuclear antigen (PCNA) and replication factor C (RFC). Also, co-transfection of a functional gene along with the DNA encoding PCNA and RFC causes stable transfection of the functional gene.

L'invention concerne la transfection stable de neurones à l'aide de l'ADN codant pour un antigène nucléaire des cellules prolifératives et un facteur de réplication C. De même, une co-transfection d'un gène fonctionnel parallèlement avec l'ADN codant pour un antigène nucléaire des cellules prolifératives et un facteur de réplication C provoque une transfection stable du gène fonctionnel.

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