A method of transfection and compositions therefor

Details A method of transfection and compositions therefor A method of transfection and compositions therefor

A - Human Necessities

61

K

A61K 39/00 (2006.01)

Patent

CA 2702154

The present invention relates to the targeted delivery of molecules to cells expressing toll-like receptors (TLRs). Aspects of the invention provide compounds comprising a positively charged group linked to a TLR ligand. These compounds are useful for in vitro and in vivo methods of transfection of TLR-expressing cells. Other aspects of the invention relate to the use of such compounds for repression of gene expression and DNA vaccination approaches.

Cette invention concerne l'administration ciblée de molécules dans des cellules exprimant les récepteurs de type Toll (TLR). Certains aspects de l'invention proposent des composés comprenant un groupe chargé positivement lié à un ligand de TLR. Ces composés sont utilisés dans des procédés in vitro et in vivo de transfection des cellules exprimant les TLR. D'autres aspects de l'invention concernent l'utilisation de ces composés dans la répression de l'expression génique et les approches de la vaccination par ADN.

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