A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/12 (2006.01) A61K 35/76 (2006.01) A61K 39/00 (2006.01) A61K 39/125 (2006.01) A61K 39/215 (2006.01) A61K 39/235 (2006.01) A61K 39/245 (2006.01) A61P 35/00 (2006.01) A61P 35/04 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2422429
There is disclosed a method of killing abnormal cells such as malignant cells including melanoma cells, using a virus recognising at least one of a cell adhesion molecule and a complement regulatory protein. The virus may be a member of the Picornaviridae family. Coxsackie A-group viruses have been found to be particularly suitable. The cell adhesion molecule is desirably a member of the immunoglobulin (Ig) superfamily. Typically, the complement regulatory protein will be DAF.
L'invention concerne un procédé d'élimination de cellules anormales, telles que des cellules malignes dont les cellules de mélanomes, reposant sur l'utilisation d'un virus reconnaissant au moins une molécule d'adhésion cellulaire et une protéine régulatrice de complément. Le virus peut être un membre de la famille Picornaviridae. Des virus Coxsackie groupe A se sont révélés être particulièrement appropriés. La molécule d'adhésion cellulaire est de préférence un membre de la superfamille des immunoglobulines (Ig). La protéine régulatrice de complément est généralement une protéine membranaire DAF.
Blake Cassels & Graydon Llp
University Of Newcastle Research Associates Limited The
Viralytics Limited
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