A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/12 (2006.01) A61K 35/76 (2006.01) A61K 39/125 (2006.01) A61P 35/00 (2006.01) C12N 7/00 (2006.01)
Patent
CA 2510227
There are provided methods for treatment of abnormal cells such as cancer cells in a mammal. The methods involve treating the mammal with virus selected from echoviruses and modified forms and combination thereof, which recognise .alpha.2.beta.1 for infectivity of the cells. There are also provided methods for screening viruses for use in a method of the invention as well as pharmaceutical compositions for use in the methods.
L'invention concerne des méthodes permettant de traiter des cellules anormales, telles que des cellules cancéreuses chez un mammifère. Lesdites méthodes impliquent de traiter le sujet concerné avec un virus sélectionné dans les échovirus, des formes modifiées et une combinaison des deux, qui reconnaissent .alpha.¿2?.beta.¿1? pour l'infectivité des cellules. L'invention concerne également des méthodes de criblage de virus à utiliser dans une méthode selon l'invention, de même que des compositions pharmaceutiques s'utilisant dans lesdites méthodes.
Blake Cassels & Graydon Llp
Viralytics Limited
Virotarg Pty Limited
LandOfFree
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