C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/475 (2006.01) A61K 38/18 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C12N 15/18 (2006.01) C12N 15/63 (2006.01) C12P 21/06 (2006.01)
Patent
CA 2688145
The present disclosure encompasses the protein BAH, and two cleavage products thereof, Vstat120 and Vstat40. The disclosure also describes the use of BAH, and two cleavage products thereof, Vstat120 and Vstat40, as an anti-angiogenic and anti-tumorigenic therapy for gliomas as well as its other types of cancer and conditions involving aberrant angiogenesis. One aspect of the disclosure therefore provides a polypeptide, derived from the protein BAH, comprising an integrin binding domain and a thrombospondin type 1 repeat. Another aspect of the disclosure provides methods of inhibiting the formation of a tumor sustained or disseminated by angiogenesis, comprising: contacting a developing tumor with one of the polypeptides derived from the protein BAM whereupon angiogenesis is inhibited, and thereby inhibiting the formation of the tumor. Another aspect of the disclosure is pharmaceutical compositions comprising a Vstat120 and Vstat40 polypeptide, or variants thereof, an at least one carrier for delivery to an animal or human patient.
L'invention concerne la protéine BAH, et deux produits de clivage de celle-ci, Vstat120 et Vstat40. L'invention concerne également l'utilisation de BAH, et de deux produits de clivage de celle-ci, Vstat120 et Vstat40, en tant que thérapie anti-angiogénique et anti-tumorigène pour des gliomes ainsi que d'autres types de cancer et des affections impliquant une angiogenèse aberrante. Un aspect de l'invention concerne donc un polypeptide, dérivé de la protéine BAH, comprenant un domaine de liaison à l'intégrine et une répétition de type 1 de thrombospondine. Un autre aspect de l'invention concerne un procédé d'inhibition de la formation d'une tumeur soutenue ou disséminée par angiogenèse, comprenant la mise en contact d'une teneur en cours de développement avec l'un des polypeptides dérivés de la protéine BAM, sur quoi l'angiogenèse est inhibée, et ainsi l'inhibition de la formation de la tumeur. Un autre aspect de l'invention concerne des compositions pharmaceutiques comprenant un polypeptide Vstat120 et Vstat40, ou des variantes de celui-ci, et au moins un support pour administration à un patient animal ou humain.
Emory University
Sim & Mcburney
LandOfFree
A method of treating abnormal angiogenesis via the bai... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with A method of treating abnormal angiogenesis via the bai..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and A method of treating abnormal angiogenesis via the bai... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1464124