A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 35/12 (2006.01) A61K 35/28 (2006.01) A61P 3/10 (2006.01) A61K 48/00 (2006.01) C12N 5/10 (2006.01)
Patent
CA 2499215
The present invention relates generally to a method for treating or ameliorating the symptoms of or reducing or otherwise minimizing the risk of development of an autoimmune disease such as but not limited to autoimmune diabetes. More particularly, the present invention relates to the use of genetically modified hemopoietic stem cells and/or hemopoietic progenitor cells which express genetic material encoding one or more autoantigens which give rise to antigen-presenting cells that induce immune tolerance and/or protective immunity. The present invention provides, therefore, a method for the treatment and/or prophylaxis of autoimmune disease conditions such as type 1 diabetes.
L'invention concerne un procédé pour traiter une maladie auto-immune ou réduire les symptômes de cette dernière ou réduire au minimum les risques de développer une maladie auto-immune, telle que le diabète. L'invention concerne plus particulièrement l'utilisation de cellules souches homopoïétiques et/ou de cellules progénitrices homopoïétiques, génétiquement modifiées, qui expriment le matériel génétique codant un ou plusieurs auto-antigènes qui donnent naissance à des cellules de présentation de l'antigène induisant une tolérance immunitaire et/ou une immunité protectrice. L'invention concerne par conséquent un procédé pour le traitement et/ou la prophylaxie de maladies auto-immunes telles que le diabète de type 1.
Harrison Leonard Charles
Steptoe Raymond John
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
The Walter And Eliza Hall Institute Of Medical Research
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