A method of treating bacterial infection of sutures and...

A - Human Necessities – 61 – K

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A61K 39/395 (2006.01) A61K 38/08 (2006.01) A61K 38/17 (2006.01) A61K 38/49 (2006.01) A61L 17/00 (2006.01) A61L 27/00 (2006.01) A61L 29/00 (2006.01) C07K 16/28 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2252484

An agent capable of inhibiting signalling mediated by a .beta.1 integrin cell surface receptor of leukocyte cells will treat a bacterial infection associated with a surface of a foreign body over and around which fibrin has been deposited, or a malignant tumor over and around which tenascin has been deposited. In addition, coating a foreign body with a fibrinolytic agent will prevent chronic bacterial infection associated with the surface of the foreign body. Furthermore, an agent capable of stimulating signalling mediated by a .beta.1 integrin cell surface receptor of leukocyte cells will treat chronic inflammation.

Un agent capable d'inhiber la signalisation induite par le récepteur de surface cellulaire, l'intégrine .beta.¿1?, des cellules leucocytaires, est apte à traiter une infection bactérienne associée à une surface d'un corps étranger sur lequel et autour duquel de la fibrine a été déposée, ou une tumeur maligne sur laquelle ou autour de laquelle de la ténascine a été déposée. En outre, l'application d'un revêtement d'un agent fibrinolytique sur un corps étranger permet de prévenir les infections bactériennes chroniques associées à la surface dudit corps étranger. Un agent capable de stimuler la signalisation induite par le récepteur de surface cellulaire, l'intégrine .beta.¿1?, de cellules leucocytaires, sera également apte à traiter une inflammation chronique.

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