A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/05 (2006.01) A61K 31/16 (2006.01) A61K 31/195 (2006.01) A61K 31/40 (2006.01) A61K 31/415 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) A61K 38/00 (2006.01) A61K 38/06 (2006.01) A61K 45/06 (2006.01) C07D 233/26 (2006.01) C07D 295/192 (2006.01) C07D 309/30 (2006.01) C07D 401/12 (2006.01) C07D 403/06 (2006.01) C07D 403/14 (2006.01)
Patent
CA 2251955
The present invention relates to a method of treating cancer which comprises administering to a mammalian patient an effective amount of a combination of geranylgeranyl-protein transferase-type I inhibitor and a farnesyl protein transferase inhibitor. The invention further relates to a method of treating cancer which comprises administering to a mammalian patient an effective amount of a combination of a selective geranylgeranyl-protein transferase-type I inhibitor and a selective farnesyl protein transferase inhibitor. The figure shows the autoradiograph of the immunoprecipates from assay set No. 1 of the in vivo prenylation inhibition by a combination by a selective of FPTase inhibitor and a selective geranylgeranyl-protein transferase-type I inhibitor.
Méthode de traitement anticancéreux consistant à administrer à un patient mammifère une dose efficace d'une combinaison composée d'un inhibiteur de géranylgéranyle-protéine transférase-tpye I et un inhibiteur de farnésyle protéine transférase. L'invention porte en outre sur une méthode de traitement du cancer consistant à administrer à un patient mammifère une dose efficace d'une combinaison d'un inhibiteur sélectif de géranylgéranyle-protéine transférase-type I et d'un inhibiteur sélectif de farnésyle protéine transférase.
Gibbs Jackson B.
Kohl Nancy E.
Oliff Allen I.
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
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