A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/495 (2006.01) A61K 31/00 (2006.01) A61K 31/498 (2006.01) A61K 31/50 (2006.01) A61K 31/5025 (2006.01) A61P 35/00 (2006.01) C07D 241/36 (2006.01) C07D 487/02 (2006.01) C12N 9/12 (2006.01)
Patent
CA 2442264
The present invention is directed to a method of treating cancer which comprises administration of a compound which selectively inhibits the activity of one or two of the isoforms of Akt, a serine/threonine protein kinase. The invention is particularly directed to the method wherein the compound is dependent on the presence of the plestrin homology domain of Akt for its inhibitory activity.
La présente invention concerne une méthode de traitement du cancer consistant en l'administration d'un composé lequel inhibe sélectivement l'activité d'une ou de deux des isoformes de Akt, une sérine/ thréonine protéine kinase. L'invention concerne notamment la méthode dans laquelle le composant dépend de la présence du domaine d'homologie de plestrine d'Akt pour son activité inhibitrice.
Barnett Stanley F.
Defeo-Jones Deborah
Haskell Kathleen M.
Huber Hans E.
Nahas Deborah D.
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
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