A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2643592
The present invention is directed to compounds, agents, pharmaceutically active agents, medicaments, therapeutics, actives, drugs and the like which specifically target a portion of the HAS molecule which is accessible to the extracellular environment in a first form of a cell but which is not accessible to the extracellular environment in another form of or in a transformed cell form the same or related cell. In particular, the present invention provides compounds which target a portion of HAS which is accessible to the extracellular environment in malignant or inflammatory or proliferative cells but which portion is not accessible to the external environment in "normal" cells. A "normal" cell in this instance is a non-malignant, inflammatory or proliferative cell.
La présente invention concerne des composés, des agents, des agents pharmaceutiquement actifs, des médicaments, des agents thérapeutiques, des agents actifs, des drogues et similaires, qui visent spécifiquement une partie de la molécule HAS qui est accessible à l'environnement extracellulaire dans une première forme de cellule, mais ne l'est plus dès lors que la forme est différente ou transformée dans une même cellule ou une cellule apparentée. En particulier, la présente invention concerne des composés qui visent une partie de HAS qui est accessible à l'environnement extracellulaire dans des cellules prolifératives malignes ou inflammatoires, mais dont ladite partie n'est pas accessible à l'environnement externe dans des cellules 'normales'. Une cellule 'normale' dans le présent exemple est une cellule non maligne, inflammatoire ou proliférative.
Brown Tracey
Brownlee Gary
Alchemia Oncology Limited
Ridout & Maybee Llp
LandOfFree
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