A method of treating cancer using dichloroacetate

Details A method of treating cancer using dichloroacetate A method of treating cancer using dichloroacetate

A - Human Necessities

61

K

A61K 31/19 (2006.01) A61P 35/00 (2006.01) C12Q 1/00 (2006.01)

Patent

CA 2604625

The invention relates to the use of dichloroacetate and chemical equivalents thereof for the treatment of cancer by inducing apoptosis or reversing apoptosis-resistance in a cell Preferably, the dosage is 10-100 mg/kg Preferably, sodium dichloroacetate is used. The dichloroacetate may optionally be given in combination with a pro-apoptotic agent and/or a chemotherapeutic agent Preferably, the cancers treated are non-small cell lung cancer, glioblastoma and breast carcinoma.

L'invention concerne l'utilisation de dichloroacétate et de ses équivalents chimiques dans le traitement du cancer par déclenchement de l'apoptose ou inversement de la résistance à l'apoptose dans une cellule. De préférence, le dosage est de 10-100 mg/kg. De préférence, du dichloroacétate de sodium est utilisé. Le dichloroacétate peut être éventuellement administré en combinaison avec un agent pro-apoptotique et/ou un agent chimiothérapeutique. De préférence, les types de cancer traités sont le cancer du poumon "non à petites cellule", le glioblastome et le cancer du sein.

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