A method of treating neurodegenerative diseases

A - Human Necessities – 61 – K

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A61K 38/21 (2006.01) A61K 35/14 (2006.01) A61K 38/18 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2709662

This invention provides compositions and methods for treating a subject suffering from a disease or disorder of the nervous system, associated with an inflammatory response. This invention further provides a pharmaceutical composition comprising, inter alia, an agent which increases brain levels of interferon-.gamma.; and an agent which reduces the number of brain T regulatory (Treg) cells, and optionally further comprising an agent which suppresses neurotoxic inflammatory brain responses.

La présente invention concerne des compositions et des procédés de traitement d'un sujet souffrant d'une maladie ou d'un trouble du système nerveux, lié à une réaction inflammatoire. Cette invention concerne en outre une composition pharmaceutique comprenant, notamment, un agent qui augmente les niveaux cérébraux d'interféron-?, et un agent qui réduit le nombre de lymphocytes T régulateurs du cerveau (Treg). En outre, la composition comprend éventuellement un agent qui supprime les réactions cérébrales inflammatoires neurotoxiques.

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