A method of treating tumors using fas-induced apoptosis

Details A method of treating tumors using fas-induced apoptosis A method of treating tumors using fas-induced apoptosis

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 48/00 (2006.01) C07K 14/435 (2006.01) C07K 14/705 (2006.01) C12N 15/62 (2006.01) C12N 15/63 (2006.01) C12N 15/861 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2347847

The present invention provides a method of killing a Fas+ tumor cell comprising introducing into a second tumor cell a nucleic acid encoding a Fas ligand (FasL), whereby the second tumor cell expresses the nucleic acid thereby producing FasL, and whereby interaction of the Fas+ tumor cell with the second tumor cell expressing FasL causes the Fas+ tumor cell to undergo apoptosis, thereby killing the Fas+ tumor cell.

La présente invention concerne une technique de destruction des cellules tumorales Fas?+¿, consistant à introduire dans une seconde cellule tumorale des acides nucléiques codant le ligand Fas (FasL). La seconde cellule tumorale exprime les acides nucléiques produisant ainsi le FasL et l'interaction de la cellule tumorale Fas?+¿ avec la seconde cellule tumorale exprimant FasL déclenche l'apoptose de la cellule tumorale Fas?+¿, détruisant ainsi cette cellule.

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