A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/135 (2006.01) A61K 31/4164 (2006.01) A61K 31/55 (2006.01) A61K 45/06 (2006.01) A61P 15/12 (2006.01)
Patent
CA 2502027
The present invention relates to the use of compounds and composition of compounds that modulate norepinephrine levels for the treatment of vasomotor symptoms such as thermoregulatory disorders. Furthermore, the present invention relates to the use of compounds and compositions of compounds having norepinephrine reuptake inhibitor (NRI) activity alone or norepinephrine reuptake inhibitor and serotonin reuptake inhibitor (NRI/SRI) dual activity in combination with 5-HT2a receptor antagonist activity.
L'invention concerne l'utilisation de composés et d'une composition de composés qui modulent les taux de noradrénaline pour le traitement des symptômes vasomoteurs tels que les troubles de la thermorégulation. L'invention concerne également l'utilisation de composés et de compositions de composés présentant une activité unique d'inhibition du recaptage de la noradrénaline (NRI) ou une activité double de d'inhibition du recaptage de la noradrénaline et d'inhibition du recaptage de la sérotonine (NRI/SRI) conjointement avec une activité antagoniste du récepteur 5-HT¿2a?.
Deecher Darlene Coleman
Merchenthaler Istvan Jozsef
Smart & Biggar
Wyeth
LandOfFree
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