A method of treatment and an animal model useful for same

A - Human Necessities – 01 – K

Patent

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Details

A01K 67/027 (2006.01) C07K 14/47 (2006.01) C12N 15/12 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2304132

The present invention relates generally to a method of treatment and to an animal model for the identification of molecules and genetic sequences useful in a method of treatment including inducing or reducing fertility of male animals. More particularly, the present invention contemplates a method for the treatment of infertility or a method of reducing fertility and even more particularly a method for modulating spermatogenesis in an animal or avian species. There is also provided an animal model comprising a mutation in at least one allele of bcl-w or in a gene associated with bcl-w. Such animals fail to undergo productive spermatogenesis and can be used to screen for therapeutic molecules including genetic sequences capable of inducing, enhancing or otherwise facilitating spermatogenesis in said animals as well as a model for molecules and genetic sequences which can induce infertility.

De manière générale, l'invention concerne une méthode de traitement et un modèle animal qui permettent d'identifier des molécules et des séquences géniques utiles pour ladite méthode de traitement, notamment pour induire ou réduire la fertilité des animaux mâles. Plus particulièrement, l'invention concerne une méthode permettant de traiter la stérilité ou une méthode permettant de réduire la fertilité et, encore plus particulièrement, une méthode permettant de moduler la spermatogenèse chez un animal ou une espèce aviaire. L'invention concerne également un modèle animal qui comporte une mutation au niveau d'au moins un allèle de bcl-w ou d'un gène associé à bcl-w. Ces animaux, qui ne présentent pas de spermatogenèse productive, peuvent être utilisés pour cribler des molécules thérapeutiques, y compris des séquences génétiques, capables d'induire, d'améliorer ou de faciliter d'une autre manière leur spermatogenèse. Ils peuvent également servir de modèles pour des molécules et des séquences géniques capables d'induire la stérilité.

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