A method of treatment and prophylaxis

Details A method of treatment and prophylaxis A method of treatment and prophylaxis

A - Human Necessities

61

K

A61K 38/00 (2006.01) A01K 67/027 (2006.01) A61K 38/18 (2006.01) A61P 37/00 (2006.01) C07K 14/52 (2006.01) C12N 15/19 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2401343

The present invention relates generally to a method for the treatment and/or prophylaxis of a disease condition, agents useful in such treatments and an animal model useful in screening and evaluating potentially efficacious therapeutic agents. More particularly, the present invention contemplates a method for the treatment and/or prophylaxis of a local or systemic autoimmune condition such as but not limited to rheumatoid arthritis or a related condition. The method of the present invention is predicated in part on the determination that the onset and/or severity of particular disease conditions is exacerbated or otherwise facilitated by certain growth factors or cytokines. Temporary or sustained reduction in the levels of these growth factors or cytokines is shown to reduce the onset and/or severity and/or to otherwise ameliorate the conditions of the disease conditions.

L'invention concerne de manière générale un traitement curatif et/ou préventif pour une pathologie, des agents utiles pour ces traitement et un modèle animal utile pour l'identification et l'évaluation d'agents thérapeutiques potentiellement efficaces. L'invention concerne plus particulièrement un traitement curatif et/ou préventif pour une pathologie auto-immune locale ou systémique, notamment, mais non exclusivement, la polyarthrite rhumatoïde ou une pathologie similaire. Cette méthode de traitement est fondée en partie sur la reconnaissance que l'apparition ou la gravité de maladies particulières est exacerbée ou stimulée d'une autre manière par certains facteurs de croissance ou certaines cytokines. Il a été démontré qu'une réduction temporaire ou continue des taux de ces facteurs de croissance ou cytokines permet de réduire l'apparition et/ou la gravité de la maladie et/ou d'améliorer d'une autre manière les conditions de cette maladie.

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