G - Physics – 01 – V
Patent
G - Physics
01
V
G01V 3/00 (2006.01) G01R 33/46 (2006.01) G01R 33/465 (2006.01)
Patent
CA 2490305
The present invention presents a new approach to rapidly obtaining precise high-dimensional NMR spectral information, named "GFT NMR spectroscopy", which is based on the phase sensitive joint sampling of the indirect dimensions spanning a subspace of a conventional NMR experiment. The phasesensitive joint sampling of several indirect dimensions of a high-dimensional NMR experiment leads to largely reduced minimum measurement times when compared to FT NMR. This allows one to avoid the "sampling limited" data collection regime. Concomitantly, the analysis of the resulting checmical shift multiplets, which are edited by the G-matrix transformation, yields increased precision for the measurement of the chemical shifts. Additionally, methods of conducting specific GFT NMR experiments as well as methods of conducting a combination of GFT NMR experiments for rapidly obtaining precise chemical shift assignment and determining the structure of proteins or other molecules are disclosed.
L'invention concerne une nouvelle approche permettant d'obtenir rapidement des informations spectrales RMN hautement dimensionnelles pr~cises, systme d~sign~ par <= spectroscopie GFT RMN >=, bas~sur un ~chantillonnage conjoint sensible ~ la phase, des dimensions indirectes couvrant un sous-espace d'un essai conventionnel RMN. L'~chantillonnage conjoint sensible ~ la phase de plusieurs dimensions indirectes d'un essai RMN hautes dimensions permet d'avoir des temps de mesure minimums nettement r~duits, comparativement ~ FT RMN. Ceci permet d'~viter le r~gime de collecte de donn~es <= ~chantillonnage limit~ >=. En mÚme temps, l'analyse des multiplets ~ d~placement chimique qui en r~sultent, lesquels sont ~dit~s par la transform~e de matrice G, fournit une pr~cision accrue de la mesure des d~placements chimiques. L'invention concerne en outre des proc~d~s permettant d'effectuer des essais sp~cifiques GFT RMN, ainsi que des proc~d~s permettant d'effectuer une combinaison d'essais GFT RMN offrant la possibilit~ d'une obtention rapide d'attribution pr~cise de d~placements chimiques, ainsi que d'une d~termination de la structure de prot~ines ou d'autres mol~cules.
Atreya Hanudatta S.
Kim Seho
Szyperski Thomas A.
Gowling Lafleur Henderson Llp
The Research Foundation Of State University Of New York
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