A method selecting an immunotherapeutic preparation

A - Human Necessities – 61 – K

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A61K 39/395 (2006.01)

Patent

CA 2534886

The present invention relates to a method for selecting one or more immunotherapeutic preparation having improved properties as a vaccine against a target antigen, said method comprising raising antibodies against a group of candidate preparations and selecting one or more preparations which produces antibodies having higher affinity against the target antigen than does antibodies raised against at least one other preparation from the group. More particularly it relates to the need to provide recombinat allergens (Bet V 1) for SIT which have been modified by protein engineering.

La présente invention concerne une méthode de sélection d'une ou de plusieurs préparations immunothérapeutiques ayant des propriétés améliorées en tant que vaccins contre un antigène cible, ladite méthode consistant à développer des anticorps contre un groupe de préparations candidates et à sélectionner une ou plusieurs préparations produisant des anticorps ayant une affinité supérieure contre l'antigène cible par rapport à des anticorps développés contre au moins une autre préparation du groupe. L'invention concerne plus particulièrement la nécessité de produire des allergènes recombinés (Bet V 1) pour SIT ayant été modifiés par ingénierie des protéines.

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