A method to diagnose schizophrenia using blood

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2500272

It is intended to provide an objective method of diagnosing integration dysfunction syndrome with the use of gene expression in mononuclear cells in peripheral blood as an indication. This method is characterized by comprising comparing a gene expression profile in mononuclear cells in blood collected from a test subject with that of a normal subject or a patient with integration dysfunction syndrome and examining the occurrence of a statistically significant variation in the quantitative gene data of the test subject to thereby judge whether or not the test subject suffers from integration dysfunction syndrome.

La présente invention concerne un procédé visant à diagnostiques le syndrome de dysfonction d'intégration en utilisant comme indication l'expression génique dans des cellules mononucléaires du sang périphérique. Ce procédé est caractérisé en ce qu'il comporte une comparaison de profil d'expression génique de cellules mononucléaires du sang prélevé chez un sujet de test avec celui d'un sujet normal ou d'un patient souffrant du syndrome de dysfonction d'intégration, puis un examen de l'occurrence d'une variation statistiquement significative des données géniques quantitatives du sujet de test, permettant de savoir si le sujet de test souffre ou non du syndrome de dysfonction d'intégration.

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