A method to incorporate n-(4-hydroxyphenyl) retinamide in...

A - Human Necessities – 61 – K

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A61K 45/06 (2006.01) A61K 9/127 (2006.01) A61K 31/165 (2006.01) A61K 38/13 (2006.01) A61K 38/21 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2425196

Disclosed herein are simple and unique methods of methods of preparing liposomal compositions of N-(4-hydroxyphenyl) retinamide (4HPR) and/or other retinoids. Also disclosed are liposomal 4HPR compositions prepared by such methods and use of such compositions in the treatment of diseases, such as breast cancer. This invention further provides methods for improving the efficacy of N-(4-hydroxyphenyl) retinamide (4HPR) as a chemopreventive agent in the presence of agents that potentiates its ability increase the expression of inducible nitric oxide synthase (iNOS), and NO production in cells.

La présente invention concerne des procédés simples et uniques servant à préparer des compositions liposomales de <i>N</i>-(4-hydroxyphényl) rétinamide (4HPR) et/ou d'autres rétinoïdes. Cette invention concerne également des compositions liposomales de 4HPR préparées grâce auxdits procédés, ainsi que l'utilisation desdites compositions dans le cadre du traitement de maladies telles que le cancer du sein. L'invention a également pour objet des procédés servant à améliorer l'efficacité de <i>N</i>-(4-hydroxyphényl) rétinamide (4HPR) en tant qu'agent chimio-préventif en la présence d'agents qui potentialisent son aptitude à augmenter l'expression de l'oxyde nitrique synthase inductible (iNOS), et la production de NO dans les cellules.

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