G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/566 (2006.01) C12N 5/02 (2006.01) C12Q 1/02 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/567 (2006.01) G01N 33/58 (2006.01) G01N 33/88 (2006.01)
Patent
CA 2453652
The present invention provides cell lines expressing endogenous PGD2-specific receptors, methods for increasing expression of the receptors and assays utilizing the hereindisclosed cell lines for identifying modulators of the PGD2-specific receptors. Increasing expression of PGD2-specific receptors is achieved by treating the disclosed cell lines with an agent that induces differentiation.
La présente invention concerne des lignées cellulaires exprimant des récepteurs endogènes spécifiques de PGD¿2?, des méthodes pouvant augmenter l'expression desdits récepteurs, et des dosages mettant en oeuvre ces lignées cellulaires pour identifier des modulateurs des récepteurs spécifiques de PGD¿2?. Une expression accrue des récepteurs spécifiques de PGD¿2? s'obtient par traitement des lignées cellulaires de l'invention avec un agent qui induit la différenciation.
Gervais Francois
Metters Kathleen Mary
O'neill Gary
Gowling Lafleur Henderson Llp
Merck Frosst Canada & Co./merck Frosst Canada & Cie
Merck Frosst Canada Ltd.
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