A method to produce highly pure eicosapentaenoic acid or its...

C - Chemistry – Metallurgy – 11 – B

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C11B 7/00 (2006.01) C07C 51/44 (2006.01) C07C 51/47 (2006.01) C07C 57/03 (2006.01) C07C 67/54 (2006.01) C07C 67/56 (2006.01) C07C 69/587 (2006.01) C11B 3/10 (2006.01) C11B 3/12 (2006.01) C11C 1/08 (2006.01) C11C 1/10 (2006.01)

Patent

CA 2122345

A mixture of fatty acids or their ester derived from natural oils and fats including eicosapentaenoic acids or their derivatives is precision distilled under a high vacuum using a plurality of distillation columns, three distilla- tion columns or more in particular, in order to acquire a fraction consisting mainly of fatty acids of carbon number 20 or their ester, which is then subjected to a column chromatography with a reversed-phase distribution system. Eicosapentaenoic acids or their ester, which is useful for preventing or treating thrombus, with purity as high as 99 % and above and with recovery rate 55 % or above, is produced.

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