A micro-rna family that modulates fibrosis and uses thereof

C - Chemistry – Metallurgy – 12 – N

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C12N 5/10 (2006.01) C12N 15/113 (2010.01) A01K 67/027 (2006.01) A61K 31/7105 (2006.01) A61P 9/00 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2694930

The present invention relates to the identification of a microRNA family, designated miR-29a-c, that is a key regulator of fibrosis in cardiac tissue. The inventors show that members of the miR-29 family are down-regulated in the heart tissue in response to stress, and are up-regulated in heart tissue of mice that are resistant to both stress and fibrosis. Also provided are methods of modulating expression and activity of the miR-29 family of miRNAs as a treatment for fibrotic disease, including cardiac hypertrophy, skeletal muscle fibrosis other fibrosis related diseases and collagen loss-related disease.

L'invention concerne l'identification d'une famille de micro-ARN appelée miR-29a/c, qui constitue un régulateur majeur de la fibrose dans un tissu cardiaque. Selon l'invention, les éléments de la famille miR-29 sont régulés à la baisse dans le tissu cardiaque en réaction au stress, et sont régulés à la hausse dans le tissu cardiaque de souris qui sont résistantes à la fois au stress et à la fibrose. L'invention concerne également des procédés de modulation de l'expression et de l'activité de la famille de micro-ARN miR-29 permettant de traiter des maladies fibrotiques comprenant l'hypertrophie cardiaque, la fibrose musculaire squelettique, et d'autres maladies associées à la fibrose ou associées à une perte de collagène.

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