A modified glutamic acid decarboxylase (gad)

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/60 (2006.01) A61K 31/70 (2006.01) A61K 38/51 (2006.01) A61K 39/00 (2006.01) A61K 48/00 (2006.01) C12N 9/88 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2230128

A modified GAD especially characterized by a substantially preserved immunogenicity in connection with diabetes compared with a non-modified GAD and a reduced or non-existent effectivity in connection with a GABA-synthesis. The invention relates also to a method for manufacturing a modified GAD, a method for supplying a modified GAD, nucleotide sequence encoding the modified GAD, a vector containing the nucleic acid sequence, a host, a pharmaceutical composition comprising modified GAD and use thereof for treating and/or preventing autoimmune disorders such as IDDM.

La présente invention concerne une DAG modifiée, particulièrement caractérisée par une immunogénicité sensiblement préservée vis-à-vis du diabète, comparée à une DAG non modifiée, et par une activité réduite ou nulle vis-à-vis d'une synthèse de GABA. L'invention concerne aussi un procédé de fabrication d'une DAG modifiée, un procédé d'obtention d'une DAG modifiée, une séquence de nucléotide codant la DAG modifiée, un vecteur contenant la séquence d'acide nucléique, un hôte, une composition pharmaceutique contenant la DAG modifiée et l'emploi de celle-ci pour le traitement et/ou la prévention des affections auto-immunes telles que le diabète insulino-dépendant.

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