A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61P 11/00 (2006.01)
Patent
CA 2697378
The present invention relates to modulators of the Neuregulin (NRG) family, particularly NRG1 and more particularly NRG1ß, and most particularly NRG1ß1. The present invention also relates to the use of such modulators to inhibit goblet cell hyperplasia and therefore also relates to the use of such modulators in the treatment or prevention of human diseases and disorders featuring pathological mucus production such as COPD, CF, chronic bronchitis and asthma.
La présente invention concerne des modulateurs de la famille des neurégulines (NRG), en particulier NRG1, mieux NRG1ß, et idéalement NRG1ß1. L'invention concerne également l'utilisation de tels modulateurs pour inhiber l'hyperplasie des cellules calciformes; elle concerne donc également l'utilisation de tels modulateurs dans le traitement ou la prévention de maladies et troubles humains entraînant la production de mucus pathologique, tels que la MPOC, la mucoviscidose, la bronchite chronique et l'asthme.
Jackson Alan
Jones Carol Elizabeth
Fetherstonhaugh & Co.
Novartis Ag
LandOfFree
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