C - Chemistry – Metallurgy – 40 – B
Patent
C - Chemistry, Metallurgy
40
B
C40B 40/00 (2006.01) C07B 61/00 (2006.01) C07K 1/04 (2006.01) C40B 30/04 (2006.01) C40B 50/00 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2400338
The invention relates to the field of molecular recognition or detection of discontinuous or conformational binding sites or epitopes corresponding to a binding molecule, in particular in relation to protein-protein protein-nucleic acid, nucleic acid-nucleic acid or biomolecule-ligand interactions. The invention provides a synthetic molecular library allowing testing for, identification, characterisation or detection of a discontinuous binding site capable of interacting with a binding molecule, said library having been provided with a plurality of molecules, each molecule of said molecules comprising at least one first segment linked to a second segment, each segment having the capacity of being a potential single part of a discontinuous binding site.
L'invention concerne le domaine de la reconnaissance ou de la détection moléculaire de sites de liaison ou d'épitopes discontinus et conformationnels correspondant à une molécule de liaison, notamment en rapport avec des interactions protéine-protéine protéine-acide nucléique, acide nucléique-acide nucléique ou biomolécule-ligand. Cette invention met en place une librairie de molécules synthétiques permettant de contrôler l'identification, la caractérisation ou la détection d'un site de liaison capable d'interagir avec une molécule de liaison, cette librairie ayant été alimentée en molécules, chacune de ces molécules comprend au moins un premier segment lié à un second segment, chaque segment pouvant être une seule partie d'un site de liaison continu.
Puijk Wouter Cornelis
Slootstra Jelle Wouter
Van Dijk Evert
Borden Ladner Gervais Llp
Pepscan Systems B.v.
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