A molecule and chimeric molecules thereof

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/535 (2006.01) A61K 38/19 (2006.01) A61K 38/20 (2006.01) A61P 7/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01) C07K 14/52 (2006.01) C07K 14/54 (2006.01) C07K 14/565 (2006.01) G01N 33/543 (2006.01)

Patent

CA 2597795

The present invention relates generally to the fields of proteins, diagnostics, therapeutics and nutrition. More particularly, the present invention provides an isolated protein molecule in or related to the IL-6 protein family such as G-CSF, IL-11, IL-6, LIF or chimeric molecules thereof, comprising at least a portion of the protein molecule; wherein the protein or chimeric molecule thereof has a profile of measurable physiochemical parameters, wherein the profile is indicative of, associated with or forms the basis of one or more pharmacological traits. The present invention further contemplates the use of the isolated protein or chimeric molecule thereof in a range of diagnostic, prophylactic, therapeutic, nutritional and/or research applications.

La présente invention concerne de façon générale les domaines des protéines, des diagnostics, des thérapeutiques et de la nutrition. Plus particulièrement, la présente invention concerne une molécule de type protéine isolée appartenant ou apparentée à la famille de la protéine IL-6 telle que le G-CSF, l'IL-11, l'IL-6, le LIF ou des molécules chimères de celle-ci comprenant au moins une partie de la molécule de type protéine ; la protéine ou la molécule chimère de celle-ci ayant un profil de paramètres physiochimiques mesurables, le profil étant indicateur de la base d'un ou plusieurs traits pharmacologiques ou étant associé à celle-ci ou formant celle-ci. La présente invention concerne également l'utilisation de la protéine isolée ou de la molécule chimère de celle-ci dans toutes sortes d'applications de diagnostic, prophylactiques, thérapeutiques, nutritionnelles et/ou de recherche.

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