C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/54 (2006.01) A23D 9/00 (2006.01) C12N 1/19 (2006.01) C12N 9/10 (2006.01) C12N 15/63 (2006.01) C12N 15/81 (2006.01) C12P 7/64 (2006.01)
Patent
CA 2622398
The present invention relates to a fungal C16/18 fatty acid elongase that is able to catalyze the conversion of palmitate (16:0) to stearic acid (18:0). Specifically, the nucleotide sequence of a Mortierella alpina C16/18 fatty acid elongase is provided (designated as ~ELO3~). Methods of increasing microbial oil production, increasing carbon flux into the polyunsaturated fatty acid biosynthetic pathway and increasing the content of polyunsaturated fatty acids by over-expression of the C16/18 fatty acid elongase are described herein. Most desirably, the substrate specificity of the instant ELO3 will be particularly useful to enable accumulation of long-chain polyunsaturated fatty acids in oleaginous yeast, such as Yarrowia lipolytica.
La présente invention concerne une élongase fongique des acides gras en C16/18 qui est capable de catalyser la conversion du palmitate (16/0) en acide stéarique (18/0). L'invention concerne spécifiquement la séquence nucléotidique d'une élongase d'acides gras en C16/18 tirée de Mortierella alpina (désignée ~ELO3~). L'invention concerne des procédés d'augmentation de la production d'huile microbienne, d'augmentation du flux de carbone dans la voie de la bio-synthèse des acides gras polyinsaturés et d'augmentation de la teneur en acides gras polyinsaturés par la sur-expression de l'élongase d'acides gras en C16/18. Idéalement, la spécificité de substrat de la présente ELO3 sera particulièrement utile pour permettre l'accumulation d'acides gras polyinsaturés à longue chaîne dans une levure oléagineuse telle que Yarrowia lipolytica.
Macool Daniel Joseph
Xue Zhixiong
Zhu Quinn Qun
E.i. Du Pont de Nemours And Company
Torys Llp
LandOfFree
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