C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/85 (2006.01) A01K 67/02 (2006.01) A01K 67/027 (2006.01) C12N 15/00 (2006.01) C12Q 1/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01)
Patent
CA 2449279
Provided herein is a mouse that is unable to express functional alpha-4- integrin protein, and methods for assaying agents for alpha-4 integrin antagonist activity, as well as genetic markers for analyzing the efficacy of VLA-4 modulators, and particularly antagonists.
L'invention concerne une souris n'exprimant pas la protéine intégrine alpha-4 fonctionnelle, ainsi que des procédés permettant de doser des agents pour l'activité d'antagonistes de l'intégrine alpha-4. L'invention concerne encore des marqueurs génétiques permettant d'analyser l'efficacité de modulateurs VLA-4, en particulier des antagonistes.
Foster Martyn
Khorkova Olga
Kirschbaum Bernhard
Polites Gregory
Wasel-Nielen Monika
Aventis Pharmaceuticals Inc.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
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